Wilms' Tumor--A Clinical Review

Adult Wilms' tumor: review of literature.

BACKGROUND The most common renal tumors in adults is renal cell carcinoma. Wilms' tumor in subjects older than 16 years is rare; only 3% of Wilms' tumors are reported in adults, which explain the difficulties in diagnosis and treatment of this tumor entity in this age group. METHODS Patient with stage IV adult nephroblastoma with favorable histology was described, current treatment modalities...

MiR-21 Expression in Wilms’ Tumor

Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children...

Wilms Tumor

[Wilms' tumor].

Today the prognosis in children with nephroblastoma is excellent. With the combination of surgery, chemotherapy and radiation more than 80% of children can be cured. Because of acute toxicity and late effects of treatment (scoliosis, cardiotoxicity, fertility problems and second malignancies) a major issue in the management of children with this kind of malignancy is the reduction of chemothera...

Bilateral Wilms tumour: a review of clinical and molecular features

Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately one in 10 000 children. The tumour is associated with undifferentiated embryonic lesions called nephrogenic rests (NRs) or, when diffuse, nephroblastomatosis. WT or NRs can occur in both kidneys, termed bilateral disease, found in only 5-8% of cases. Management of bilateral WT presents a major clinical chall...